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USC-OGP 2-DE database
Two-dimensional polyacrylamide gel electrophoresis database
USC-OGP 2-DE database
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Searching in 'USC-OGP 2-DE database' for entry
matching:
Q9NPJ6
USC-OGP 2-DE database
:
Q9NPJ6
Q9NPJ6
General information about the entry
View entry in simple text format
Entry name
MED4_HUMAN
Primary accession number
Q9NPJ6
integrated into USC-OGP 2-DE database on
January 17, 2017 (release 1)
2D Annotations were last modified on
January 17, 2017 (version 1)
General Annotations were last modified on
April 5, 2017 (version 2)
Name and origin of the protein
Description
RecName: Full=Mediator of RNA polymerase II transcription subunit 4; AltName: Full=Activator-recruited cofactor 36 kDa component; Short=ARC36; AltName: Full=Mediator complex subunit 4; AltName: Full=TRAP/SMCC/PC2 subunit p36 subunit; AltName: Full=Vitamin D3 receptor-interacting protein complex 36 kDa component; Short=DRIP36;.
Gene name
Name=MED4
Synonyms=ARC36, DRIP36, VDRIP
ORFNames=HSPC126
Annotated species
Homo sapiens (Human) [TaxID:
9606
]
Taxonomy
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]
2D GEL CHARACTERIZATION
Author 1., Author 2.
Submitted (Mar-2011) to Current
2D PAGE maps for identified proteins
How to interpret a protein
UVEAL_MELANOMA_3-10
{UVEAL MELANOMA 3-10}
Homo sapiens (Human)
map experimental info
UVEAL_MELANOMA_3-10
MAP LOCATIONS:
SPOT OGP-1299
:
pI=4.88; Mw=23684
Cross-references
UniProtKB/Swiss-Prot
Q9NPJ6; MED4_HUMAN.
2D PAGE maps for identified proteins
How to interpret a protein map
You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
Warning 1
: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
Warning 2
: the 2D PAGE map is built on demand. This may take some few seconds to be computed.
External data extracted from
UniProtKB/Swiss-Prot
Extracted from
UniProtKB/Swiss-Prot
, release:
0.0
Entry name
MED4_HUMAN
Primary accession number
Q9NPJ6
Secondary accession number(s)
B4DX67 Q53GB4 Q53H68 Q5T912 Q6FHC4 Q6IA79 Q9BS95 Q9NYR5
Sequence was last modified on
October 1, 2000 (version 1)
Annotations were last modified on
March 15, 2017 (version 147)
Name and origin of the protein
Description
RecName: Full=Mediator of RNA polymerase II transcription subunit 4; AltName: Full=Activator-recruited cofactor 36 kDa component; Short=ARC36; AltName: Full=Mediator complex subunit 4; AltName: Full=TRAP/SMCC/PC2 subunit p36 subunit; AltName: Full=Vitamin D3 receptor-interacting protein complex 36 kDa component; Short=DRIP36;
Gene name
Name=MED4
Synonyms=ARC36, DRIP36, VDRIP
ORFNames=HSPC126
Encoded on
Name=MED4; Synonyms=ARC36, DRIP36, VDRIP; ORFNames=HSPC126
Keywords
Acetylation
;
Activator
;
Alternative splicing
;
Coiled coil
;
Complete proteome
;
Direct protein sequencing
;
Nucleus
;
Phosphoprotein
;
Reference proteome
;
Transcription
;
Transcription regulation
.
Copyright
Copyrighted by the UniProt Consortium, see
http://www.uniprot.org/help/license
. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBL
AF300618; AAG22542.1
; -; mRNA
EMBL
AF230381; AAF37289.1
; -; mRNA
EMBL
AF161475; AAF29090.1
; -; mRNA
EMBL
AK001934; BAA91987.1
; -; mRNA
EMBL
CR457276; CAG33557.1
; -; mRNA
EMBL
CR541830; CAG46629.1
; -; mRNA
EMBL
AK222713; BAD96433.1
; -; mRNA
EMBL
AK301835; BAG63279.1
; -; mRNA
EMBL
AK223017; BAD96737.1
; -; mRNA
EMBL
AL158196; CAI17018.1
; -; Genomic_DNA
EMBL
AL158196; CAI17020.1
; -; Genomic_DNA
EMBL
BC005189; AAH05189.1
; -; mRNA
CCDS
CCDS59241.1; -. [Q9NPJ6-2]
; .
CCDS
CCDS9408.1; -. [Q9NPJ6-1]
; .
RefSeq
NP_001257558.1; NM_001270629.1. [Q9NPJ6-2]
; .
RefSeq
NP_054885.1; NM_014166.3. [Q9NPJ6-1]
; .
UniGene
Hs.181112; -
; .
UniGene
Hs.741275; -
; .
ProteinModelPortal
Q9NPJ6; -
; .
SMR
Q9NPJ6; -
; .
BioGrid
118849; 358
; .
IntAct
Q9NPJ6; 88
; .
MINT
MINT-1196457; -
; .
STRING
9606.ENSP00000258648; -
; .
iPTMnet
Q9NPJ6; -
; .
PhosphoSitePlus
Q9NPJ6; -
; .
DMDM
29840770; -
; .
EPD
Q9NPJ6; -
; .
MaxQB
Q9NPJ6; -
; .
PaxDb
Q9NPJ6; -
; .
PeptideAtlas
Q9NPJ6; -
; .
PRIDE
Q9NPJ6; -
; .
DNASU
29079; -
; .
Ensembl
ENST00000258648; ENSP00000258648
; ENSG00000136146. [Q9NPJ6-1]; .
Ensembl
ENST00000378586; ENSP00000367849
; ENSG00000136146. [Q9NPJ6-2]; .
GeneID
29079; -
; .
KEGG
hsa:29079; -
; .
UCSC
uc001vby.3; human. [Q9NPJ6-1]
; .
CTD
29079; -
; .
DisGeNET
29079; -
; .
GeneCards
MED4; -
; .
HGNC
HGNC:17903; MED4
; .
HPA
HPA006232; -
; .
MIM
605718; gene
; .
neXtProt
NX_Q9NPJ6; -
; .
OpenTargets
ENSG00000136146; -
; .
PharmGKB
PA134877001; -
; .
eggNOG
KOG4552; Eukaryota
; .
eggNOG
ENOG410XQ30; LUCA
; .
GeneTree
ENSGT00390000012063; -
; .
HOGENOM
HOG000043883; -
; .
HOVERGEN
HBG052450; -
; .
InParanoid
Q9NPJ6; -
; .
KO
K15146; -
; .
OMA
GLEPPGH; -
; .
OrthoDB
EOG091G0M8S; -
; .
PhylomeDB
Q9NPJ6; -
; .
TreeFam
TF324421; -
; .
Reactome
R-HSA-1989781; PPARA activates gene expression
; .
Reactome
R-HSA-212436; Generic Transcription Pathway
; .
Reactome
R-HSA-381340; Transcriptional regulation of white adipocyte differentiation
; .
ChiTaRS
MED4; human
; .
GeneWiki
MED4; -
; .
GenomeRNAi
29079; -
; .
PRO
PR:Q9NPJ6; -
; .
Proteomes
UP000005640; Chromosome 13
; .
Bgee
ENSG00000136146; -
; .
CleanEx
HS_MED4; -
; .
ExpressionAtlas
Q9NPJ6; baseline and differential
; .
Genevisible
Q9NPJ6; HS
; .
GO
GO:0070847; C:core mediator complex
; IBA:GO_Central; .
GO
GO:0016592; C:mediator complex
; IDA:UniProtKB; .
GO
GO:0016020; C:membrane
; IDA:UniProtKB; .
GO
GO:0005654; C:nucleoplasm
; IDA:HPA; .
GO
GO:0005634; C:nucleus
; IDA:UniProtKB; .
GO
GO:0030374; F:ligand-dependent nuclear receptor transcription coactivator activity
; NAS:UniProtKB; .
GO
GO:0004872; F:receptor activity
; IDA:UniProtKB; .
GO
GO:0001104; F:RNA polymerase II transcription cofactor activity
; IDA:UniProtKB; .
GO
GO:0046966; F:thyroid hormone receptor binding
; IDA:UniProtKB; .
GO
GO:0003712; F:transcription cofactor activity
; IDA:UniProtKB; .
GO
GO:0042809; F:vitamin D receptor binding
; NAS:UniProtKB; .
GO
GO:0030521; P:androgen receptor signaling pathway
; IDA:UniProtKB; .
GO
GO:0030518; P:intracellular steroid hormone receptor signaling pathway
; IDA:UniProtKB; .
GO
GO:0045893; P:positive regulation of transcription
; DNA-templated; IDA:UniProtKB
GO
GO:0006366; P:transcription from RNA polymerase II promoter
; IDA:UniProtKB; .
GO
GO:0006367; P:transcription initiation from RNA polymerase II promoter
; IDA:UniProtKB; .
InterPro
IPR019258; Mediator_Med4
; .
Pfam
PF10018; Med4
; 1; .
Gateways to other related servers
The World-2DPAGE Constellation
- Entry point to the world-wide 2-DPAGE resources.
World-2DPAGE Repository
- A public repository for gel-based proteomics data linked to protein identification published in the literature.
World-2DPAGE Portal
- A dynamic portal to query simultaneously world-wide gel-based proteomics databases.
SWISS-2DPAGE
- The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
ExPASy
- The resources web server of the
Swiss Institute of Bioinformatics
Database constructed and maintained by
Angel Garcia
, using the
Make2D-DB II
package (
ver. 3.10.2
) from the
World-2DPAGE Constellation
of the
ExPASy web server
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